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Objective:Investigate the relationship between dietary patterns and sarcopenia in a Chinese elderly population.Methods:Participants in this cross-sectional study were recruited from the Tianjin Chronic Low-grade Systemic Inflammation and Health Cohort Study. The study population comprised 2 423 participants, with mean age of (67.6±5.2) years. Sarcopenia was defined based on the guidelines of the Asian Working Group for Sarcopenia. Three dietary patterns were derived by factor analysis: fruit and sweet pattern, traditional oriental pattern, and animal food pattern. The association between quartile categories of dietary pattern scores and the presence of sarcopenia was analyzed using multiple logistic regression models. Odds ratios ( OR) and 95% confidence interval ( CI) were calculated. Results:The prevalence of sarcopenia was 16.1%. After adjusting for confounding factors, compared with the lowest quartile, the adjusted OR ( 95%CI) of sarcopenia for the highest quintile of Fruit and sweet pattern score, Traditional oriental pattern score and Animal food pattern score were 1.06 (0.74, 1.50), 0.54 (0.34, 0.86), and 0.50 (0.33, 0.74), ( P for trend were 0.87,<0.01, and<0.001), respectively. Conclusions:The current study found that the traditional oriental pattern and animal food pattern has a protective relation for sarcopenia in elderly adults, which suggests its potential to attenuate or prevent the progression of sarcopenia.
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Objective To analyze the chorological changes of diagnosis in patients with autoimmune liver disease (AILD) and related factors for early diagnosis.Methods A total of 581 patients with age ranged from 16 to 81 were retrospectively analyzed,who were admitted to Tianjin Medical University General Hospital with AILD during January 2000 to December 2017.Age at diagnosis,diagnostic method and cirrhosis at diagnosis were compared in different groups according to admission period as 2000-2005,2006-2011,2012-2017.Results The diagnostic rate of AILD showed an upward trend during the past near two decades.The proportion of AILD patients diagnosed via health examination was increasing year by year mainly by elevated transaminases (P＜0.001).The mean age at diagnosis in our AILD patients were younger at present,especially in men (P=0.044).The proportion of cirrhosis at diagnosis was gradually reduced in three different periods respectively [77.78％(21/27),41.58％ (79/190),25.00％(91/364),P＜0.001],which were coincident in patients with autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC) (P＜0.001).The shrinking trend of cirrhosis at diagnosis was significantly correlated with the increasing application of health examination (r=-0.549,P＜0.001).Conclusions Extensive application of health examination expands the diagnostic rate of AILD.During the past 18 years,more young patients are diagnosed with AILD.The proportion of severe cases such as cirrhosis at diagnosis is decreasing.Screening of immunological examinations in patients with abnormal transaminases is needed and critical to the early diagnosis of asymptomatic AILD.
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Professor's clinical experiences were introduced in the intervention on atopic dermatitis with external therapies of TCM acupuncture. On the basis of the theory as cultivating the earth and clearing the heart from professorand in terms of the disease stages and skin lesion characteristics, as well as in consideration of syndrome differen-tiation, the acupoints for strengthening the spleen and clearing heart fire are selected, such as Zhongwan (CV 12), Daheng (SP 15), Shuifen (CV 9), Tianshu (ST 25), Neiguan (PC 6) and Quchi (LI 11). For the repair of skin lesion, the integration of Chinese and western medicine is used, with the internal application and external use of Chinese herbal medicines involved. The topical ointments are selected rationally. The self-blood therapy is used with acupuncture, bleeding therapy and acupoint injection applied in combination on the basis of the theory of TCMorgans and modern immunological mechanism, which stimulates the nonspecific immune response in the body and strengthens acupoint stimulus effects. Medical thread therapy ofmedicine is used in moxibustion for skin damage, which effectively stops itching and promotes wound healing and skin repair.
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Background:The overlap of autoimmune liver disease with extrahepatic autoimmune disease adds the difficulty of diagnosis. It is essential to understand their clinical features. Aims:To analyze the clinical characteristics of primary biliary cirrhosis-autoimmune hepatitis( PBC-AIH ) overlap syndrome, and to investigate the effect of extrahepatic autoimmune disease on PBC-AIH. Methods:The clinical data including general information,clinical manifestations, biochemical parameters,immunological parameters,liver histopathological features,imaging findings and incidence of extrahepatic autoimmune disease of 81 patients with PBC-AIH were retrospectively analyzed. According to whether overlapping with extrahepatic autoimmune disease,PBC-AIH patients were divided into combination group and non-combination group. The clinical characteristics of the two groups were analyzed. Results:The ratio of male to female of 81 patients with PBC-AIH was 1 ∶ 9. 1,and the average age was(58. 1 ± 9. 9)years old. Of the patients 53. 1% had symptoms,the percentage of jaundice and pruritus was 18. 5% . Serum levels of ALT,AST,ALP,GGT,TBil and Glo were increased in all patients and IgG and IgM levels were increased in most of the patients. The positive rates of ANA, AMA and/ or AMA-M2,SMA and gp210 and/ or sp100 were 100% ,90. 1% ,1. 2% and 11. 1% ,respectively. Portal lymphoplasmacyte infiltration and interface hepatitis were the major liver histopathological features;50. 6% of the patients had both histological features of PBC and AIH. Cirrhosis was diagnosed in 28 patients(34. 6% )by imaging,and abdominal lymph nodes enlargement was found in 76 patients(93. 8% ). Twenty-three patients(28. 4% )overlapped with extrahepatic autoimmune disease;Sjogren’s syndrome and autoimmune thyroid disease were the most frequently overlapped extrahepatic autoimmune diseases. The level of GGT was significantly lower in combination group than in non-combination group(P = 0. 001). No statistically significant differences in other clinical characteristics were found between the two groups. Conclusions:It is crucial to understand the clinical characteristics of PBC-AIH and to screen the overlapped extrahepatic autoimmune disease,especially Sjogren’s syndrome and autoimmune thyroid disease.